Effects of zopiclone and temazepam on sleep, behaviour and mood
Over a 3 week period the hypnotic effect of zopiclone 7.5 mg, temazepam 20 mg and placebo was investigated in a double-blind, cross-over study in 60.
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It supports the case for not prescribing hypnotics for more than 2 weeks. The third week, which was a placebo week for all patients, showed a gradual improvement in sleep quality.
The results showed that zopiclone 7.5 mg and temazepam 20 mg were almost equally effective. The hypnotic effect, subdivided in the parameters sleep quality, latency of sleep onset and status after awaking, was scored daily by the patient after arising. In sleep quality and latency of sleep onset, there appeared to be a non-significant trend favouring zopiclone. Both hypnotics differ significantly from placebo.
Over a 3 week period the hypnotic effect of zopiclone 7.5 mg, temazepam 20 mg and placebo was investigated in a double-blind, cross-over study in 60 out-patients.
Mood and behaviour during the day, as well as somatic symptoms and side-effects, were also scored daily and showed no significant differences between the treatments.