Get tips on therapy and treatment.
Administration of theophylline or aminophylline may reduce the sedative effects of benzodiazepines, including lorazepam.
The effects of probenecid and valproate on lorazepam may be due to inhibition of glucuronidation.
In a sample of about 3500 patients treated for anxiety, the most frequent adverse reaction to Ativan (lorazepam) was sedation (15.9%), followed by dizziness (6.9%), weakness (4.2%), and unsteadiness (3.4%). The incidence of sedation and unsteadiness increased with age.
Lorazepam dosage needs to be reduced by approximay 50% when coadministered with probenecid. Concurrent administration of lorazepam with probenecid may result in a more rapid onset or prolonged effect of lorazepam due to increased half-life and decreased total clearance.
Most adverse reactions to benzodiazepines, including CNS effects and respiratory depression, are dose dependent, with more severe effects occurring with high doses.
Paradoxical reactions, including anxiety, excitation, agitation, hostility, aggression, rage, sleep disturbances/insomnia, sexual arousal, and hallucinations may occur. Small decreases in blood pressure and hypotension may occur but are usually not clinically significant, probably being related to the relief of anxiety produced by Ativan (lorazepam).
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
Last reviewed on RxList: 10/4/2010 This monograph has been modified to include the generic and brand name in many instances. Share this Article:.
Prescription Anxiety Medications »
Read the Prescription Anxiety Medications article »
It helps by increasing our awareness of what's going on around us and in other ways. For". Anxiety is both a normal and useful response to potentially stressful or dangerous situations.
The benzodiazepines, including Ativan (lorazepam), produce increased CNS-depressant effects when administered with other CNS depressants such as alcohol, barbiturates, antipsychotics, sedative/hypnotics, anxiolytics, antidepressants, narcotic analgesics, sedative antihistamines, anticonvulsants, and anesthetics.
Report Problems to the Food and Drug Administration.
Read the Ativan (lorazepam) Side Effects Center for a complete guide to possible side effects.
Concomitant use of clozapine and lorazepam may produce marked sedation, excessive salivation, hypotension, ataxia, delirium, and respiratory arrest.
Other adverse reactions to benzodiazepines, including lorazepam are fatigue, drowsiness, amnesia, memory impairment, confusion, disorientation, depression, unmasking of depression, disinhibition, euphoria, suicidal ideation/attempt, ataxia, asthenia, extrapyramidal symptoms, convulsions/seizures tremor, vertigo, eye-function/visual disturbance (including diplopia and blurred vision ), dysarthria/slurred speech, change in libido, impotence, decreased orgasm ; headache, coma; respiratory depression, apnea, worsening of sleep apnea, worsening of obstructive pulmonary disease; gastrointestinal symptoms including nausea, change in appetite, constipation, jaundice, increase in bilirubin, increase in liver transaminases, increase in alkaline phosphatase ; hypersensitivity reactions, anaphylactic/oid reactions; dermatological symptoms, allergic skin reactions, alopecia ; SIADH, hyponatremia ; thrombocytopenia, agranulocytosis, pancytopenia ; hypothermia ; and autonomic manifestations.
Here is a collection of user reviews for the medication Ativan sorted by most helpful.
Read the Ativan Drug Interactions Center for a complete guide to possible interactions.
Lorazepam dosage should be reduced to approximay 50% when coadministered with valproate. Concurrent administration of lorazepam with valproate results in increased plasma concentrations and reduced clearance of lorazepam.