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Cirrhosis sodium retention





Pathogenesis of water and sodium retention in cirrhosis

9/16/2014
02:19 | Author: Cole Thomas

Cirrhosis sodium retention
Pathogenesis of water and sodium retention in cirrhosis

Martin PY, Schrier RW. The pathogenesis of renal sodium and water retention in cirrhosis involves extrarenal mechanisms because when kidneys from cirrhotic.

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In the rat model of cirrhosis, normalization of vascular NO production with a NOS inhibitor corrects the hyperdynamic circulation, improves sodium and water excretion, and decreases neurohumoral activation. This sequence of events results in renal water and sodium retention, failure to escape from the sodium-retaining effect of aldosterone, and renal resistance to atrial natriuretic peptide. Dilutional hyponatremia is the strongest predictor of the occurrence of hepatorenal syndrome. Cirrhosis is accompanied by portal hypertension, which leads to a hyperdynamic circulatory state. Activation of the renain-angiotensin-aldosterone axis and the sympathetic system as well as non-osmotic release of vasopressin are well documented in cirrhosis. The Peripheral Arterial Vasodilation Hypothesis incriminates a relative underfilling of the arterial vascular compartment, which leads to the same neurohumoral responses that occurs in low cardiac output. Increased vascular NO production has been demonstrated in cirrhosis. The pathogenesis of renal sodium and water retention in cirrhosis involves extrarenal mechanisms because when kidneys from cirrhotic patients are transplanted into persons with normal livers, renal sodium and water retention no longer occurs. The pathogenesis of the peripheral arterial vasodilation is not compley elucidated, but there is evidence for a major role of nitric oxide (NO). This insight into the mechanism(s) of the peripheral arterial vasodilation in cirrhosis should provide new tools in the treatment of edema and ascites, a major cause of morbidity and mortality in cirrhosis.

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Cirrhosis - Wikipedia, the free encyclopedia

7/15/2014
04:02 | Author: Caitlin White

Cirrhosis sodium retention
Cirrhosis - Wikipedia, the free encyclopedia

Ascites (fluid retention in the abdominal cavity) is the most common.. restriction is often necessary, as cirrhosis leads to accumulation of salt (sodium retention).

People with ascites due to cirrhosis are at risk of spontaneous bacterial peritonitis.

While the clinical entity was known before, it was René Laennec who gave it the name "cirrhosis" (in the same 1819 work in which he also described the stethoscope ). The word "cirrhosis" derives from Greek κιρρός meaning yellowish, tawny (the orange-yellow colour of the diseased liver) + the common Greek suffix of the third declension -sis known from other Greek-originated terms (such as ly-sis, amyloido-sis, necro-sis etc.) that in Greek means "condition" (thus cirrho+sis = a yellowish condition or a condition that makes one yellowish).

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Sodium Retention in Heart Failure and Cirrhosis

5/14/2014
06:03 | Author: Christina Harris

Cirrhosis sodium retention
Sodium Retention in Heart Failure and Cirrhosis

Abstract. Patients with cirrhosis and heart failure (HF) share the pathophysiology of decreased effective arterial blood volume because of splanchnic.

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Therefore, low-dose aldosterone antagonists are being used in patients with HF for cardioprotective action. Hyperaldosteronism plays a major role in the pathogenesis of ascites and contributes to resistance to loop diuretics. Patients with cirrhosis and heart failure (HF) share the pathophysiology of decreased effective arterial blood volume because of splanchnic vasodilatation in cirrhosis and decreased cardiac output in HF, with resultant stimulation of the renin-angiotensin-aldosterone system.

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Mechanisms of water and sodium retention in cirrhosis and the

3/13/2014
08:16 | Author: Evan Martin

Sodium phosphate chemical formula
Mechanisms of water and sodium retention in cirrhosis and the

Patients with advanced cirrhosis and portal hypertension often show an abnormal regulation of extracellular fluid volume, resulting in the accumulation of fluid.

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Important Facts About Salt and Cirrhosis Liver Support Health News

1/12/2014
10:55 | Author: Kate Thompson

Cirrhosis sodium retention
Important Facts About Salt and Cirrhosis Liver Support Health News

Upon being diagnosed with cirrhosis, physicians typically advise their patients to compley avoid, Consuming salt fosters water retention.

Claria, J. Rodes, Gut, December 2001. www.gut.bmj.com, Sodium in Preascitic Cirrhosis: Please Pass the Salt, J.

· Hernia – Elevated intra-abdominal pressure from ascites can lead to the development of umbilical and inguinal hernias. Typically manifesting with abdominal discomfort, pain or an abdominal bulge, a surgical repair may be necessary.

Why Ascites Is Unwanted Aside from expanding girth around the midsection, ascites can cause the following medical complications:

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