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Phosphate transport





Phosphate-transporting ATPase - Wikipedia, the free encyclopedia

9/20/2014
02:15 | Author: Kate Thompson

Phosphate transport
Phosphate-transporting ATPase - Wikipedia, the free encyclopedia

The systematic name of this enzyme class is ATP phosphohydrolase (phosphate-importing). This enzyme is also called ABC phosphate transporter.

In enzymology, a phosphate-transporting ATPase ( EC 3.6.3.27 ) is an enzyme that catalyzes the chemical reaction.

The systematic name of this enzyme class is ATP phosphohydrolase (phosphate-importing). This enzyme is also called ABC phosphate transporter. This enzyme belongs to the family of hydrolases, specifically those acting on acid anhydrides to catalyse transmembrane movement of substances. This enzyme participates in abc transporters - general.

The 3 substrates of this enzyme are ATP, H 2 O, and phosphate, whereas its two products are ADP and phosphate.

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Crystal structure of a eukaryotic phosphate transporter Nature

7/19/2014
12:10 | Author: Caitlin White

Sodium and phosphate formula
Crystal structure of a eukaryotic phosphate transporter Nature

Here we report the 2.9 Å structure of a fungal (Piriformospora indica) high-affinity phosphate transporter, PiPT, in an inward-facing occluded.

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Phosphate transport in the kidney

5/18/2014
02:15 | Author: Kate Thompson

Phosphate transport
Phosphate transport in the kidney

Phosphate transport in the kidney. Murer H, Biber J. In kidneys of mammals, filtered phosphate ions (Pi) are reabsorbed along the proximal tubules.

National Center for Biotechnology Information, U.S. National Library of Medicine 8600 Rockville Pike, Bethesda MD, 20894 USA.

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Acute hormonal regulation of Pi reabsorption occurs mainly by a change of the abundance of SLC34A1 (NaPi-IIa) via modulation of the interaction of NaPi-IIa with the PDZ-protein NHERF1. Apical abundance of these Na/Pi-cotransporters is adjusted by numerous hormones/phosphatonins and metabolic factors in order to adjust the extent of renal Pi reabsorption according to body needs. In kidneys of mammals, filtered phosphate ions (Pi) are reabsorbed along the proximal tubules. Transcellular transport of phosphate is initiated by several apically localized sodium-dependent Pi cotransporters (Na/Pi-cotransporters) that belong to the SLC 20 (SLC20A2) and 34 (SLC34A1, SLC34A3) families.

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The regulation of renal phosphate transport

3/17/2014
04:00 | Author: Caitlin White

Phosphate transport
The regulation of renal phosphate transport

Renal phosphate transport is mediated by the abundance and activity of the sodium-dependent phosphate transporters, Npt2a, Npt2c, and PiT-2, present within.

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In general, phosphate transport is regulated by a variety of physiological stimuli, including parathyroid hormone, glucocorticoids, vitamin D3, estrogen, and thyroid hormone. This review will detail the various hormones and agents involved in the regulation of phosphate transport as well as provide a brief summary of the signaling pathways and cytoskeletal proteins active in the transport of phosphate in the renal proximal tubule. Other factors that affect phosphate transport include dopamine, dietary phosphate, acid-base status, lipid composition, potassium deficiency, circadian rhythm, and hypertension. Recent studies have demonstrated differential expression and activity of these sodium-dependent phosphate transporters within the proximal tubule. In addition, recent studies have found that NHERF-1 is also important in both the parathyroid hormone- and dopamine-mediated inhibition of phosphate transport. Studies have shown that the PDZ-containing sodium/hydrogen exchanger regulatory factor (NHERF) proteins, specifically NHERF-1 and NHERF-3, play a critical role in the physiological regulation of phosphate transport, particularly in response to dietary phosphate. Renal phosphate transport is mediated by the abundance and activity of the sodium-dependent phosphate transporters, Npt2a, Npt2c, and PiT-2, present within the apical brush border membrane of the proximal tubule. Phosphatonins are now recognized as major regulators of phosphate transport activity.

National Center for Biotechnology Information, U.S. National Library of Medicine 8600 Rockville Pike, Bethesda MD, 20894 USA.

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2011 National Kidney Foundation, Inc. Published by Elsevier Inc.

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GO0006817 - AmiGO - Gene Ontology Consortium

1/16/2014
06:35 | Author: Kate Thompson

Phosphate transport
GO0006817 - AmiGO - Gene Ontology Consortium

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