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Zopiclone mechanism





Zopiclone Full Prescribing Information, Dosage Side Effects

11/19/2014
02:37 | Author: Christina Harris

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Zopiclone Full Prescribing Information, Dosage Side Effects

Zopiclone is a cyclopyrrolone derivative with hypnotic and sedative actions, anticonvulsant and muscle relaxant.

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The mechanism of action of zopiclone. - ResearchGate

11/19/2014
04:34 | Author: Devin Garcia

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The mechanism of action of zopiclone. - ResearchGate

ABSTRACT The mechanism of action of the cyclopyrrolone hypnotic drug zopiclone involves allosteric modulation of the GABAA receptor. Zopiclone displaces.

Studies with protein-modifying agents (eg diethylpyrocarbonate) and photoaffinity labelling suggest that cyclopyrrolones bind to a domain on the GABAA receptor different from the benzodiazepine binding domain. ABSTRACT The mechanism of action of the cyclopyrrolone hypnotic drug zopiclone involves allosteric modulation of the GABAA receptor. Zopiclone does not distinguish between GABAA receptors containing different alpha-subunits (BZ(1) and BZ(2) phenotype). Zopiclone displaces the binding of -flunitrazepam with an affinity of 28 nM, and enhances the binding of the channel blocker -TBPS. The consequence of this interaction with the GABAA receptor is to potentiate responses to GABA, as can be demonstrated by electrophysiological methods. The binding of zopiclone, unlike that of hypnotic benzodiazepines, is not facilitated by GABA. Subchronic treatment of mice with high doses of zopiclone does not produce the changes in sensitivity of the GABAA receptor that are observed with hypnotic benzodiazepines.

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The mechanism of action of zopiclone

11/19/2014
06:51 | Author: Christina Harris

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The mechanism of action of zopiclone

Summary - The mechanism of action of the cyclopyrrolone hypnotic drug zopiclone involves allosteric modulation of the GABAA receptor. Zopiclone displaces.

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