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Acute phosphate nephropathy treatment





Acute Phosphate Nephropathy following Oral Sodium Phosphate

11/17/2014
03:22 | Author: Caitlin White

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Acute Phosphate Nephropathy following Oral Sodium Phosphate

Acute phosphate nephropathy is an underrecognized cause of acute in the setting of phosphate treatment for hypophosphatemic rickets (1).

Patients presented with ARF and a mean creatinine of 3.9 mg/dl at a median of 1 mo after colonoscopy. Acute phosphate nephropathy is an underrecognized cause of acute and chronic renal failure. Among the 31 patients, 21 presented with acute renal failure (ARF), were normocalcemic, and had a history of recent colonoscopy preceded by bowel cleansing with oral sodium phosphate solution (OSPS) or Visicol. During the period from 2000 to 2004, 31 cases of nephrocalcinosis were identified among the 7349 native renal biopsies processed at Columbia University.

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Acute phosphate nephropathy-an emerging threat

11/16/2014
01:16 | Author: Evan Martin

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Acute phosphate nephropathy-an emerging threat

Acute phosphate nephropathy-an emerging threat. Ori Y, Herman M, Tobar A, compley in any patient. Four required long-term erythropoietin treatment.

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All patients had hypertension. Time from colonoscopy to presentation was 56 +/- 36 days. Serum creatinine levels at presentation: 1.4 to 3.6 mg/dL. Urinalysis showed minimal proteinuria, leucocyturia, and hematuria. All patients were anemic (hemoglobin 8.8-11.4 gr/dL). One required hemodialysis. Time from colonoscopy to renal biopsy was 123 +/- 88 days. Average age was 67.4 +/- 7.0 years, with a female preponderance (4:1). Baseline serum creatinine: 0.7 to 1.2 mg/dL (creatinine clearance: 52 to 77 mL/min). Serum creatinine levels at end of follow-up were 1.3 to 3.1 mg/dL. One patient had renal glucosuria. Renal function did not recover compley in any patient. Four required long-term erythropoietin treatment. The prominent histopathological findings were calcium-phosphate tubular depositions (100%), interstitial fibrosis (80%), hypertensive changes (80%), and acute tubular degenerative and regenerative changes (60%). Mean follow-up was 36 +/- 17 months. Serum calcium and phosphate were normal.

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It is probably under-recognized. APN is a serious, irreversible renal complication of OSPS. Risk factors include female gender, older age, hypertension, and renal failure, although it may occur with preexisting normal renal function.

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In all, use of OSPS was established, and other causes of nephrocalcinosis were excluded. Five cases of APN were included, 3 retrospectively whereas 2 were diagnosed prospectively.

Approximay 25 cases have been described, but OSPS is still widely used. This study reports a further 5 cases and discusses the ever-growing significance of APN. Acute phosphate nephropathy (APN) is a clinicopathological entity causing renal failure, after ingestion of oral sodium phosphate solution (OSPS).

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Renal failure due to acute phosphate nephropathy - Welkom bij van

9/15/2014
01:26 | Author: Devin Garcia

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Renal failure due to acute phosphate nephropathy - Welkom bij van

Respond to conservative treatment and volume loading. Her previous history containing medications.3-10 Acute phosphate nephropathy has been chosen as.

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Pathogenesis of Acute Phosphate Nephropathy - Medscape Education

7/14/2014
03:52 | Author: Evan Martin

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Pathogenesis of Acute Phosphate Nephropathy - Medscape Education

Pathogenesis of Acute Phosphate Nephropathy: Oral sodium phosphate is On the basis of data from phosphate-loaded and PTH-treated rats, Asplin et al.

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Incidence and Outcome of Acute Phosphate Nephropathy in Iceland

5/13/2014
05:50 | Author: Caitlin White

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Incidence and Outcome of Acute Phosphate Nephropathy in Iceland

Cases of renal failure due to acute phosphate nephropathy (87%) all of whom were treated with either ACE-I or ARB and/or diuretics.

Index cases were found by reviewing the pathological diagnosis of renal biopsies performed in the study period. Medical records were reviewed for age, gender, medical history, medication, the ingested dose of OSPS, indication for colonoscopy and symptoms after OSPS ingestion. Estimated glomerular filtration rate (eGFR) was calculated according to the CKD-EPI (Chronic Kidney Disease Epidemiology Collaboration) equation. Patients were followed until September 30th 2009, date of starting renal replacement therapy or death, whichever came first.

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