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Eszopiclone mechanism of action





Lunesta (Eszopiclone) Drug Information Clinical Pharmacology

7/20/2014
05:30 | Author: Caitlin White

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Lunesta (Eszopiclone) Drug Information Clinical Pharmacology

The precise mechanism of action of eszopiclone as a hypnotic is unknown, but its effect is believed to result from its interaction with GABA-receptor complexes at.

In vitro studies have shown that CYP3A4 and CYP2E1 enzymes are involved in the metabolism of eszopiclone. Eszopiclone did not show any inhibitory potential on CYP450 1A2, 2A6, 2C9, 2C19, 2D6, 2E1, and 3A4 in cryopreserved human hepatocytes. Following oral administration, eszopiclone is extensively metabolized by oxidation and demethylation. The primary plasma metabolites are (S)-zopiclone-N-oxide and (S)-N-desmethyl zopiclone; the latter compound binds to GABA receptors with substantially lower potency than eszopiclone, and the former compound shows no significant binding to this receptor.

Administration of eszopiclone 3 mg to a patient taking another drug that is highly protein-bound would not be expected to cause an alteration in the free concentration of either drug.

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MOA Video LUNESTA (eszopiclone) Sunovion ProFile

5/19/2014
03:20 | Author: Caitlin White

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MOA Video LUNESTA (eszopiclone) Sunovion ProFile

The precise mechanism of action of eszopiclone as a hypnotic is unknown, but its effect is believed to result from its interaction ith the.

Sedative/hypnotic drugs should be administered with caution to patients exhibiting signs and symptoms of depression. In primarily depressed patients, worsening of depression, including suicidal thoughts and actions (including completed suicides) have been reported in association with the use of sedative/hypnotics.

subsidiary of Sumitomo Dainippon Pharma Co., Ltd. Sunovion Pharmaceuticals Inc. is a U.S.

The precise mechanism of action of eszopiclone as a hypnotic is unknown, but its effect is believed to result from its interaction ith the GABA-receptor complexes at the binding domains located close to or allosterically coupled to the GABA-binding domain (benzodiazepine receptors).

LUNESTA should not be taken together with alcohol or other sedative hypnotics.

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Eszopiclone mechanism of action - MedHelp

3/18/2014
01:30 | Author: Caitlin White

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Eszopiclone mechanism of action - MedHelp

Some socioeconomic costs of long-term benzodiazepine use Fig. 1. Diagram of mechanism of action of the natural neurotransmitter GABA (gamma aminobutyric.

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Eszopiclone Full Prescribing Information, Dosage Side Effects

11/27/2014
09:40 | Author: Caitlin White

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Eszopiclone Full Prescribing Information, Dosage Side Effects

Eszopiclone is an S-enantiomer of zopiclone; a nonbenzodiazepine hypnotic of the cyclopyrrolone class.

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