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Citicoline mechanism of action





Citicoline - Wikipedia, the free encyclopedia

10/30/2014
12:40 | Author: Caitlin White

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Citicoline - Wikipedia, the free encyclopedia

2 Mechanism of action. 2.1 Neuroprotective effects; 2.2 Neuronal membrane; 2.3 Cell signalling; 2.4 Blood flow; 2.5 Inflammation and stress; 2.6 Glutamate.

Citicoline increases glucose metabolism in the brain and cerebral blood flow.

Citicoline improves visual function in patients with glaucoma, amblyopia, and non-arteritic ischaemic optic neuropathy.

In the hippocampi of rats with induced Alzheimer’s Disease, citicoline counteracts neuronal degeneration and reduces the number of apoptotic cells present. Citicoline supplementation also improves memory retention.

When taken as a supplement citicoline is hydrolyzed into choline and cytidine in the intestine.

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Citicoline (CDP-choline) mechanisms of action and effects in

12/29/2014
10:20 | Author: Caitlin White

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Citicoline (CDP-choline) mechanisms of action and effects in

Citicoline (CDP-choline): mechanisms of action and effects in ischemic brain injury. D'Orlando KJ, Sandage BW Jr. Citicoline is approved in Europe and Japan.

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Membrane repair and regeneration is necessary for recovery from stroke. Data from many pre-clinical and clinical trials support the hypothesis that citicoline may be a safe and effective treatment for stroke. Citicoline is approved in Europe and Japan for use in stroke, head trauma and other neurological disorders. It is presently being evaluated in phase II/III stroke trials in the United States. Furthermore, citicoline may alleviate free fatty acid-induced toxicity which accompanies ischemic insult. Exogenous administration of CDP-choline provides both choline and cytidine which access the brain and serve as substrates for the synthesis of phosphatidylcholine, a primary neuronal membrane component; the choline also enhances brain acetylcholine synthesis.

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National Center for Biotechnology Information, U.S. National Library of Medicine 8600 Rockville Pike, Bethesda MD, 20894 USA.

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Citicoline neuroprotective mechanisms in cerebral ischemia

10/28/2014
08:20 | Author: Caitlin White

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Citicoline neuroprotective mechanisms in cerebral ischemia

Citicoline improved the outcome in several phase-III clinical trials of stroke, but provided inconclusive results in recent clinical trials. The therapeutic action of.

Cytidine-5'-diphosphocholine (citicoline or CDP-choline), an intermediate in the biosynthesis of phosphatidylcholine (PtdCho), has shown beneficial effects in a number of CNS injury models and pathological conditions of the brain. Our studies in transient cerebral ischemia suggest that citicoline might enhance reconstruction (synthesis) of PtdCho and sphingomyelin, but could act by inhibiting the destructive processes (activation of phospholipases). Based on these findings, a singular unifying mechanism has been hypothesized. Citicoline improved the outcome in several phase-III clinical trials of stroke, but provided inconclusive results in recent clinical trials. Citicoline neuroprotection may include: (i) preserving cardiolipin (an exclusive inner mitochondrial membrane component) and sphingomyelin; (ii) preserving the arachidonic acid content of PtdCho and phosphatidylethanolamine; (iii) partially restoring PtdCho levels; (iv) stimulating glutathione synthesis and glutathione reductase activity; (v) attenuating lipid peroxidation; and (vi) restoring Na(+)/K(+)-ATPase activity. This review attempts to shed some light on the properties of citicoline that are responsible for its effectiveness. These observed effects of citicoline could be explained by the attenuation of phospholipase A(2) activation. The therapeutic action of citicoline is thought to be caused by stimulation of PtdCho synthesis in the injured brain, although the experimental evidence for this is limited. Citicoline also provides choline for synthesis of neurotransmitter acetylcholine, stimulation of tyrosine hydroxylase activity and dopamine release.

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National Center for Biotechnology Information, U.S. National Library of Medicine 8600 Rockville Pike, Bethesda MD, 20894 USA.

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Citicoline Uses, Side Effects, Interactions and Warnings - WebMD

8/27/2014
06:20 | Author: Caitlin White

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Citicoline Uses, Side Effects, Interactions and Warnings - WebMD

Find patient medical information for citicoline on WebMD including its uses, effectiveness, side effects and safety, interactions, user ratings and products that.

Citicoline in the treatment of Parkinson's disease. Marti Masso, J. and Urtasun, M. View abstract. F. Clin.Ther 1991;13(2):239-242.

Hide Names. 5'-Cytidine diphosphate choline, CDPC, CDP Choline, CDP-Choline, Citicholine, Citicolina, Cytidine 5-Diphosphocholine, Cytidine 5'-diphosphocholine, Cytidine (5') diphosphocholine, Cytidine Diphosphate Choline, Cytidine Diphosphocholine, Cytidin. See All Names 5'-Cytidine diphosphate choline, CDPC, CDP Choline, CDP-Choline, Citicholine, Citicolina, Cytidine 5-Diphosphocholine, Cytidine 5'-diphosphocholine, Cytidine (5') diphosphocholine, Cytidine Diphosphate Choline, Cytidine Diphosphocholine, Cytidinediphosphocholine.

Human Psychopharmacology: Clinical and Experimental 1997;12(6):547-556.

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Citicoline Indication and Nursing Management Nursing Crib

6/26/2014
04:40 | Author: Caitlin White

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Citicoline Indication and Nursing Management Nursing Crib

Classification: Neurotonics, Nootropics. Mechanism of Action. Citicoline seems to increase a brain chemical called phosphatidylcholine.

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