A comparison of the efficacy, safety and withdrawal effects of
A comparison of the efficacy, safety and withdrawal effects of zopiclone and triazolam in the treatment of insomnia. Fleming JA, McClure DJ, Mayes C, Phillips R.
National Library of Medicine 8600 Rockville Pike, Bethesda MD, 20894 USA. National Center for Biotechnology Information, U.S.
A greater number of zopiclone subjects experienced a transient modification of taste which disappeared with discontinuation of therapy. Withdrawal effects were evaluated with a withdrawal symptom checklist and the CGI (withdrawal). A double-blind study comparing zopiclone and triazolam, in 48 healthy, chronic insomniacs, was undertaken in two centers to compare the hypnotic and withdrawal effects of both compounds. However, a larger number of triazolam subjects withdrew from the study because of ineffectiveness or adverse side-effects. Results indicated that both compounds improved sleep and were equally effective. During the investigation, a 17 item post-sleep questionnaire was completed daily, the Clinical Global Impression (CGI) scale weekly, and the Hamilton Anxiety Scale (HAM-A) at baseline and at the end of the study. Comparable doses of 7.5 mg zopiclone and 0.25 mg triazolam were given at bedtime for 21 nights after a 3 day wash-out period, followed by 4 placebo nights of withdrawal monitoring. Significant deterioration in nearly all sleep parameters were noted after the first withdrawal night of triazolam; much fewer modifications of sleep parameters were observed following the discontinuation of zopiclone.
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