The frequency of cardiovascular adverse reactions that require therapy is rare, hence, experience with their treatment is limited. Whenever severe hypotension or complete AV block occurs following oral administration of verapamil, the appropriate emergency measures should be applied immediay, e.g., intravenously administered isoproterenol HCl, norepinephrine bitartrate, atropine sulfate (all in the usual doses), or calcium gluconate (10% solution). If further support is necessary, ( dopamine HCl or dobutamine HCl) may be administered. Actual treatment and dosage should depend on the severity of the clinical situation and the judgment and experience of the treating physician. In patients with hypertrophic cardiomyopathy (IHSS), alpha-adrenergic agents (phenylephrine HCl, metaraminol bitartrate or methoxamine HCl) should be used to maintain blood pressure, and isoproterenol and norepinephrine should be avoided.
Easy-to-read and understand detailed drug information and pill images for the patient or caregiver from Cerner Multum.
Digestive System: diarrhea, dry mouth, gastrointestinal distress, gingival hyperplasia.
Our Isoptin SR (verapamil HCl) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.
The procedure is already available in Europe and ".
Report Problems to the Food and Drug Administration.
Here is a collection of user reviews for the medication Isoptin SR sorted by most helpful.
Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Hemic and Lymphatic: ecchymosis or bruising.
Read the entire FDA prescribing information for Isoptin (Verapamil Hydrochloride Tablet) »
During pregnancy, verapamil should be used only when prescribed. The starting dose of sustained-release verapamil is 180 mg, given in the morning. l your doctor all medications you use. Verapamil may interact with other blood pressure medications, buspirone, carbamazepine, cimetidine, cyclosporine, digoxin, lithium, lovastatin, phenobarbital, rifampin, theophylline, sedatives, antibiotics, antifungals, beta-blockers, heart rhythm medications, or HIV/AIDS medicine. Consult your doctor before breast-feeding. This medication passes into breast milk but it is unlikely to harm a nursing infant.
Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. This is not a complete list of side effects and others may occur.
Constipation 7.3% Fatigue 1.7% Dizziness 3.3% Dyspnea 1.4% Nausea 2.7% Bradycardia (HR < 50/min) 1.4% Hypotension 2.5% AV Block-total (1°,2°, 3°) 1.2% Headache 2.2% 2 ° and 3° 0.8% Edema 1.9% Rash 1.2% CHF/Pulmonary Edema 1.8% Flushing 0.6% (see WARNINGS ).
Skin: arthralgia and rash, exanthema, hair loss hyperkeratosis, maculae, sweating, urticaria, Stevens-Johnson syndrome, erythema multiforme.
The following reactions, reported in 1.0% or less of patients, occurred under conditions (open trials, marketing experience) where a causal relationship is uncertain; they are listed to alert the physician to a possible relationship.
What is Prescribing information?
In the US - Call your doctor for medical advice about side effects. In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at. A very serious allergic reaction to this drug is rare. To lower your risk of dizziness and lightheadedness, get up slowly when rising from a sitting or lying position. Many people using this medication do not have serious side effects. Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. l your doctor immediay if any of these unlikely but serious side effects occur: swelling ankles/feet, shortness of breath, unusual tiredness, unexplained/sudden weight gain, severe dizziness, fainting, very slow heartbeat. Read the entire patient information overview for Isoptin (Verapamil Hydrochloride Tablet) ». However, seek immediate medical attention if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing. If you notice other effects not listed above, contact your doctor or pharmacist. This is not a complete list of possible side effects. l your doctor immediay if any of these rare but very serious side effects occur: severe stomach/abdominal pain, dark urine, yellowing eyes/skin, persistent nausea/vomiting. You may report side effects to FDA at 1-800-FDA-1088.
Less serious side effects may include:
Visit the FDA MedWatch website or call 1-800-FDA-1088. You are encouraged to report negative side effects of prescription drugs to the FDA.
Call your doctor at once if you have any of these serious side effects:
Urogenital: gynecomastia, impotence, galactorrhea / hyperprolactinemia, increased urination, spotty menstruation.
In clinical trials related to the control of ventricular response in digitalized patients who had atrial fibrillation or atrial flutter, ventricular rates below 50/min at rest occurred in 15% of patients and asymptomatic hypotension occurred in 5% of patients.
The FDA package insert formatted in easy-to-find categories for health professionals and clinicians.
Read the New Procedure May Aid Stubborn High Blood Pressure article »
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This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
New Procedure May Aid Stubborn High Blood Pressure »
Cardiovascular: angina pectoris, atrioventricular dissociation, chest pain, claudication, myocardial infarction, palpitations, purpura ( vasculitis ), syncope.
"Dec. 18, 2012 -- People who can't get their high blood pressure down with drugs may be helped by a new procedure that deactivates overactive nerves in the kidneys, a small study shows.
What is Patient Information in Detail?
A concise overview of the drug for the patient or caregiver from First DataBank.
Special Senses: blurred vision, tinnitus.
Medical Editor: John P. Cunha, DO, FACOEP.
Get tips on handling your hypertension.
What is Patient Information Overview?
Nervous System: cerebrovascular accident, confusion, equilibrium disorders, insomnia, muscle cramps, parasthesia, psychotic symptoms, shakiness, somnolence, extrapyramidal symptoms.
Serious adverse reactions are uncommon when verapamil therapy is initiated with upward dose titration within the recommended single and total daily dose. Reversible (upon discontinuation of verapamil) non-obstructive, paralytic ileus has been infrequently reported in association with the use of verapamil. See WARNINGS for discussion of heart failure, hypotension, elevated liver enzymes, AV block, and rapid ventricular response. The following reactions to orally administered verapamil occurred at rates greater than 1.0% or occurred at lower rates but appeared clearly drug-related in clinical trials in 4,954 patients.
Read the entire detailed patient monograph for Isoptin (Verapamil Hydrochloride Tablet) »
The brand name Isoptin SR is discontinued in the U.S. Common side effects include dizziness, slow heartbeat, constipation, nausea, headache, and tiredness. Generic versions may be available. Isoptin SR (verapamil HCl) is used to treat hypertension (high blood pressure), angina (chest pain), and certain heart rhythm disorders. It is a calcium channel blocker.
Verapamil Side Effects Weight Gain